Increase in Neutrophil Lymphocyte Ratio in COVID-19 Patients Based on Symptom Severity
Main Article Content
Keywords
Neutrophil lymphocyte ratio (NLR), COVID-19, symptom severity
Abstract
The neutrophil lymphocyte ratio (NLR) is an indicator of the presence of a systemic inflammatory response. The neutrophil lymphocyte ratio parameter was calculated by comparing the number of neutrophils and the number of lymphocytes. Patients with severe COVID-19 who did not survive were found to have a higher neutrophil lymphocyte ratio compared to patients with a mild prognosis. This
study uses a descriptive method, which aims to describe the value of the neutrophil lymphocyte ratio in COVID-19 patients based on the severity of symptoms. The average value of high neutrophil lymphocyte ratio (NLR) in COVID-19 patients occurred in the severe (6.12%) and critical (10.78%) categories. The average value of high neutrophils (Neutrophilia) in COVID-19 patients occurred in the severe (76%) and critical (82%) categories. The average value of low lymphocytes (lymphocytopenia) in COVID-19 patients occurred in the severe 17% and critical 12% category. The NLR value in patients with the severe category had an increase in the NLR value twice the
normal value, while in the critical category had an increase in the NLR value three times the normal value.
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[7] I. G. A. A. A. Pramita, P. U. S. Pramana, and I. D. P. S. uma Masyuni, “Nilai rasio neutrofil-limfosit sebagai prediktor kasus COVID-19 serangan berat pada pasien dewasa,” vol. 12, no. 2, pp. 530–533, 2021, doi: 10.15562/ism.v12i2.1093.
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[12] A. Gürağaç and Z. Demirer, “The neutrophil-to-lymphocyte ratio in clinical practice,” Apr. 01, 2016, Canadian Medical Association. doi: 10.5489/cuaj.3587.
[13] Liu J et al., “Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage.,” J Transl Med, vol. 18, no. 1, p. 206, May 2020.
[14] Nayha Tahir and Farah Zahra, Neutrophilia. Treasure Island (FL): StatPearls Publishing, 2023. Accessed: Oct. 24, 2024. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK570571/
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[20] D. A. Amanda, “Rasio Neutrofil-Limfosit pada COVID-19; Sebuah tinjauan literatur,” Wellness And Healthy Magazine, vol. 2, no. 2, 2020, doi: 10.30604/well.0202.8200100.
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[27] D. Scozzi, F. Liao, A. S. Krupnick, D. Kreisel, and A. E. Gelman, “The role of neutrophil extracellular traps in acute lung injury,” Jul. 29, 2022, Frontiers Media S.A. doi: 10.3389/fimmu.2022.953195.
[28] N. U. Avtenyuk, N. Visser, E. Bremer, and V. R. Wiersma, “The neutrophil: The underdog that packs a punch in the fight against cancer,” Nov. 01, 2020, MDPI AG. doi: 10.3390/ijms21217820.
[29] U. Sahu, D. Biswas, A. K. Singh, and P. Khare, “Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection,” Jun. 01, 2021, Springer. doi: 10.1007/s13337-021-00687-2.
[30] S. Shouman et al., “SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147,” Dec. 01, 2024, BioMed Central Ltd. doi: 10.1186/s12964-024-01718-3.
[31] J. Fu et al., “The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China,” Thromb Res, vol. 192, 2020, doi: 10.1016/j.thromres.2020.05.006.
[32] R. Mus, T. Thaslifa, M. Abbas, and Y. Sunaidi, “Studi Literatur: Tinjauan Pemeriksaan Laboratorium pada Pasien COVID-19,” Jurnal Kesehatan Vokasional, vol. 5, no. 4, 2021, doi: 10.22146/jkesvo.58741.
[33] P. R. A. Sangging, A. Tjiptaningrum, I. Kurniati, and S. C. Syafrullah, “Hubungan Rasio Neutrofil Limfosit (NLR) dan Rasio Monosit Limfosit (MLR) dengan Prediktor Keparahan pada Pasien COVID-19,” Jurnal Kedokteran Universitas Lampung, vol. 5, no. 2, 2021.
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Nov 26, 2024
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Prasetya, H. R., Muhajir, N. F., Wati, M. R., & Murtiningrum, S. (2024). Increase in Neutrophil Lymphocyte Ratio in COVID-19 Patients Based on Symptom Severity. Jurnal Ilmiah Biologi Eksperimen Dan Keanekaragaman Hayati (J-BEKH), 11(2), 13–22. Retrieved from https://jurnalbiologi.fmipa.unila.ac.id/index.php/jbekh/article/view/374
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