Effect of Juice Berry Fruit (Antidesma bunius (L.) Spreng.) on Total Cholesterol Levels in Mice (Mus musculus Linnaeus, 1758) with Hypercholesterolemia Pemberian Jus Buah Buni (Antidesma bunius (L.) Spreng) terhadap Kadar Kolesterol Total pada Mencit Jantan (Mus musculus Linnaeus, 1758) Hiperkolesterolemia
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Abstract
Hypercholesterolemia is influenced by excessive fat consumption. To lower blood cholesterol levels, both drug and non-drug therapy can be carried out. One plant that has the potential to lower cholesterol levels is the buni plant (Antidesma bunius (L.) Spreng.). This study aims to determine the effect of buni fruit juice and the most effective juice concentration in lowering total cholesterol levels in hypercholesterolemic male mice. This study used a completely randomized design consisting of 5 groups, each repeated 5 times. The experimental animals were given a High Fat Diet (MDTL) containing propylthiouracil (PTU) at a dose of 1.8 mg/200g BW suspended in 2% Pure Grain Alcohol (PGA) and 10 mL/KgBW of quail egg yolk. The treatments consisted of a negative control (standard feed); a positive control (MDTL and 0.52 mg simvastatin); P1 (MDTL and 1 ml of 20% buni fruit juice); P2 (MDTL and 1 ml of 25% berry juice); and P3 (MDTL and 1 ml of 30% berry juice). Treatments P1, P2, and P3 were administered MDTL for 14 days, followed by berry juice for another 14 days. The results were total blood cholesterol levels. Data were analyzed using a one-way ANOVA followed by Duncan's test at a confidence level of α = 5%. The results showed that administration of 30% berry juice reduced total cholesterol levels in male mice with hypercholesterolemia.
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References
[1] D. A. Saputri and A. Novitasari, “Hubungan pola konsumsi dengan kadar kolesterol masyarakat di Kota Bandar Lampung,” Serambi Saintia: Jurnal Sains dan Aplikasi, vol. 9, no. 1, pp. 8–22, 2021.
[2] H. Yuningrum, M. E. Rahmuniyati, and T. D. P. Lende, “Konsumsi gorengan dan asupan kolesterol berhubungan dengan kejadian hiperkolesterolemia pada mahasiswa,” Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa, vol. 9, no. 2, pp. 98–108, 2022.
[3] F. Chairani, M. Pembayun, and A. Mursyid, “Aktivitas anti-hiperlipidemia pada uji in vivo dari kombinasi ekstrak daun alpukat (Persea americana Mill) dan rimpang temulawak (Curcuma xanthorrhiza Roxb) pada tikus dengan hiperkolesterolemia,” Jurnal Ilmiah Farmasi Farmasyifa, vol. 7, no. 2, pp. 97–105, 2024.
[4] D. Sugiyama et al., “Hypercholesterolemia and lifetime risk of coronary heart disease in the general Japanese population: Results from the Suita Cohort Study,” Journal of Atherosclerosis and Thrombosis, vol. 27, no. 1, pp. 60–70, 2020.
[5] F. D. P. Melati, F. L. Widiany, and I. Inayah, “Asupan lemak jenuh dengan kadar kolesterol low density lipoprotein pada lansia hiperkolesterolemia,” Jurnal Nutrisia, vol. 23, no. 1, pp. 44–51, 2021.
[6] Kementerian Kesehatan Republik Indonesia, Laporan Riset Kesehatan Dasar Republik Indonesia, Badan Penelitian dan Pengembangan Kementerian Kesehatan Republik Indonesia, 2023.
[7] N. S. Bachtiar, N. Isdiany, A. I. Hapsari, and Y. Moviana, “Pemberian jus stroberi dan edukasi dapat menurunkan kadar kolesterol total penderita hiperkolesterolemia,” Jurnal Gizi dan Dietetik, vol. 3, no. 1, pp. 21–33, 2024.
[8] N. Lestari et al., “Frekuensi konsumsi junk food, asupan karbohidrat sederhana dan kadar kolesterol total pada karyawan Universitas Esa Unggul,” Journal of Current Health Sciences, vol. 3, no. 1, pp. 1–6, 2023.
[9] Kementerian Kesehatan Republik Indonesia, Hasil Riset Kesehatan Dasar (Riskesdas) 2018, Badan Penelitian dan Pengembangan Kesehatan Kementerian RI, 2018.
[10] L. R. Agung, “Pengaruh daun salam (Syzygium polyanthum) terhadap kadar trigliserida dan kolesterol total darah pada penderita dislipidemia,” Jurnal Ilmiah Kesehatan Sandi Husada, vol. 10, no. 2, pp. 408–412, 2021.
[11] M. E. Benge, “Pengaruh pemberian ekstrak etanol daun afrika (Vernonia amygdalina Del.) terhadap kadar LDL serum tikus hiperkolesterolemia,” CHMK Pharmaceutical Scientific Journal, vol. 3, no. 1, pp. 103–108, 2020.
[12] Y. Gusnelti and E. Nurjanah, “Pengaruh pemberian ekstrak etanol daun sirsak (Annona muricata L.) terhadap kadar kolesterol total pada mencit (Mus musculus),” Jurnal Medisains Kesehatan, vol. 3, no. 1, pp. 6–13, 2022.
[13] B. F. J. Putri, “Evaluasi penggunaan statin dan prediksi risiko penyakit kardiovaskular aterosklerosis pada pasien dislipidemia dengan metode Pooled Cohort Risk Assessment Equation,” Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, vol. 4, no. 1, 2020.
[14] A. H. Julyaningsih, I. Yuliana, and T. Binalopa, “Penentuan perlakuan terbaik formulasi sari buah buni sebagai minuman fungsional menggunakan Analytic Hierarchy Process (AHP),” Dewantara Journal of Technology, vol. 3, no. 1, pp. 5–9, 2022.
[15] N. F. Bakri, “Uji efektivitas hipokolesterolemik jus buah buni (Antidesma bunius Linn.) pada mencit jantan (Mus musculus),” Jurnal Biogenerasi, vol. 7, no. 2, pp. 100–105, 2022.
[16] N. Nuralifah, W. Wahyuni, P. Parawansah, and U. D. Shintia, “Uji aktivitas antihiperlipidemia ekstrak etanol daun notika (Arcboldiodendron calosericeum Kobuski) terhadap kadar kolesterol total tikus (Rattus norvegicus) jantan galur Wistar,” Journal Syifa Sciences and Clinical Research (JSSCR), vol. 2, no. 1, pp. 1–10, 2020.
[17] M. Mariana, A. Rahmadi, and H. Syahrumsyah, “Pengaruh pemberian cuka mandai terhadap kadar kolesterol total, lipoprotein dan trigliserida pada mencit (Mus musculus) dengan induksi kuning telur,” Journal of Tropical AgriFood, vol. 2, no. 1, pp. 45–52, 2020.
[18] R. Vanessa, L. M. Purwijantiningsih, and Y. Aida, “Pemanfaatan minuman serbuk instan kayu manis (Cinnamomum burmanii Bl.) untuk menurunkan kadar kolesterol total darah pada tikus putih (Rattus norvegicus),” pp. 1–14, 2014.